Cov teebmeem tsis zoo ntawm cov tshuaj tua yoov tshaj cum hluav taws xob rau cov menyuam nas

Indonesia yog lub teb chaws sov, ua rau nws yog qhov chaw yug yoov tshaj cum. Qhov feem pua ​​​​​​ntawm cov yoov tshaj cum loj hlob tau ua rau muaj kev ntsuas los daws qhov teeb meem no, ib qho ntawm cov no yog kev siv cov tshuaj tua yoov tshaj cum -tshuaj tua kab thiab ntau yam tshuaj lom neeg.
Cov tshuaj tua yoov tshaj cum muaj ntau yam khoom xyaw nquag, xws li d-allethrin, trans-flufenicol, bioallethrin, dimethoate, pyrifluquinazone, d-phenetrin,cypermethrin,los yog isoprenepyrine, tag nrho cov no yog cov tshuaj pyrethroid. Cov tshuaj pyrethroid yog cov tshuaj tua kab uas tuaj yeem ua rau cov kab tsis txav tau los ntawm kev lom lawv lub paj hlwb. Cov tshuaj tua yoov tshaj cum muaj nyob rau hauv kev lag luam ua cov tshuaj tsuag, cov tshuaj coils, cov tshuaj emulsions, thiab cov tshuaj tua hluav taws xob.

Siv cov tshuaj tua yoov tshaj cum thiab lwm yam tshuaj tua kab ntau dhau yam tsis muaj kev paub txaus tuaj yeem ua rau muaj kev phom sij. Cov teeb meem tsis zoo no tuaj yeem cuam tshuam rau tib neeg, ib puag ncig, thiab cov yoov tshaj cum lawv tus kheej. Cov kev tshawb fawb yav dhau los los ntawm Almahdi et al. (2014) thiab Rahayuningsih (2006) tau qhia tias kev raug cov nas cev xeeb tub rau cov tshuaj tua yoov tshaj cum uas muaj trans-fluorometholone ua rau cov menyuam hauv plab tsis zoo thiab qhov hnyav yug me nyuam qis. Qhov no qhia tau hais tias cov tshuaj tua yoov tshaj cum yuav muaj cov teeb meem tsis zoo rau cov poj niam cev xeeb tub, vim tias cov poj niam muaj kev rhiab heev rau cov tshuaj thaum cev xeeb tub.
Cov nas siv tau ua cov tsiaj hauv chav kuaj hauv kev tshawb fawb txog kev ua rau muaj menyuam hauv plab tsis zoo uas lub hom phiaj yog kom tau txais cov ntaub ntawv txog kev ua tsis zoo ntawm cov menyuam hauv plab los ntawm kev siv cov tshuaj tua yoov thaum lub sijhawm tsim cov qe menyuam. Cov kws tshawb fawb xav kawm ntxiv txog cov teebmeem teratogenic ntawm lwm cov tshuaj tua yoov uas muaj cov khoom xyaw nquag permethrin rau qhov hnyav, qhov ntev ntawm lub cev, thiab qhov tsis zoo ntawm cov qauv ntawm cov nas (Mus musculus) menyuam hauv plab. Kev nqus cov tshuaj tua kab mus sij hawm ntev tuaj yeem ua rau muaj kev lom thiab ua rau muaj kev tsis zoo ntawm cov ntshav, cov tshuaj lom neeg, thiab cov cytokine, nrog rau kev puas tsuaj rau cov ntaub so ntswg mutagenic.

Lub hom phiaj ntawm txoj kev tshawb fawb no yog txhawm rau txiav txim siab txog cov teebmeem teratogenic ntawm cov tshuaj tua kab mob hluav taws xob rau cov menyuam hauv plab (Mus musculus). Cov tshuaj tua kab mob hluav taws xob siv muaj 0.566% (4.2 mg/mL) ntawm cov khoom xyaw nquag permethrin, uas cov nas cev xeeb tub tau nqus thaum lub sijhawm organogenesis (hnub 6-15 ntawm kev xeeb tub). Peb caug tus nas cev xeeb tub tau muab faib ua tsib pawg (rau qhov rov ua dua hauv txhua pawg): pawg C (pawg tswj, tsis muaj kev raug tshuaj tua kab mob hluav taws xob); pawg T1 (4 teev ntawm kev raug tshuaj tua kab mob hluav taws xob txhua hnub); pawg T2 (6 teev ntawm kev raug tshuaj tua kab mob hluav taws xob txhua hnub); pawg T3 (8 teev ntawm kev raug tshuaj tua kab mob hluav taws xob txhua hnub); thiab pawg T4 (10 teev ntawm kev raug tshuaj tua kab mob hluav taws xob txhua hnub). Qhov hnyav ntawm tus menyuam hauv plab thiab qhov ntev ntawm lub cev tau ntsuas, thiab kev tshuaj xyuas lej tau ua tiav los ntawm kev siv kev tshuaj xyuas ib txoj kev sib txawv (ANOVA) thiab Duncan's multiple comparisons test. Cov kev xeem Kruskal-Wallis thiab Mann-Whitney tau siv los tshuaj xyuas cov nqi yug me nyuam tseem muaj sia (%), cov menyuam tuag (%), thiab cov qauv tsis zoo (%). Cov txiaj ntsig tsis qhia txog cov qauv tsis zoo, tab sis pom muaj kev los ntshav ntawm daim tawv nqaij. Muaj qhov sib txawv tseem ceeb hauv qhov hnyav thiab ntev ntawm tus menyuam hauv plab, cov nqi yug me nyuam tseem muaj sia (%), cov menyuam tuag (%), thiab kev los ntshav (%) (p<0.05). Cov nqi siab tshaj plaws ntawm kev tuag hauv plab thiab los ntshav tau pom tom qab 10 teev ntawm kev siv cov tshuaj tua yoov hluav taws xob txhua hnub.