Cov yam ntxwv ntawm kev ua haujlwm ntawm fluconazole

Fluoxapyr yog ib qho carboxamidetshuaj tua kab mobtsim los ntawm BASF. Nws muaj cov haujlwm tiv thaiv thiab kho mob zoo. Nws yog siv los tiv thaiv thiab tswj cov kab mob fungal dav dav, tsawg kawg 26 hom kab mob fungal. Nws tuaj yeem siv rau yuav luag 100 qoob loo, xws li cov qoob loo cereal, legumes, cov qoob loo roj, txiv laum huab xeeb, txiv pome thiab cov ntoo txiv hmab txiv ntoo pob zeb, cov hauv paus thiab cov zaub tuber, txiv hmab txiv ntoo zaub thiab paj rwb, nplooj lossis noob kho. Fluoxafenamide yog ib qho succinate dehydrogenase inhibitor thiab yog ib qho fungicide zoo heev tsim nyob rau hauv xyoo tas los no.
Cov khoom siv tshuaj lom neeg ntawm fluconazole

Fluconazole Lub Npe Tshuaj: 3-(difluoromethyl)-1-methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide, 3-(difluoro Methyl)-1-methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide; CAS No: 907204-31-3, Cov mis molecular: C18H12F5N3O. Qhov hnyav molecular: 381.31 g/mol.Fluoxapyr (purity 99.3%) yog ib qho khoom dawb rau beige, tsis muaj ntxhiab, melting point 156.8 ℃, qhov ceev ntawm qhov sib piv (20 ℃) ​​1.42 g / mL, decomposes ntawm txog 230 ℃, vapor siab (kwv yees): 2.7 × 10-9 Pa (20 ° C), 8.1 × 10-9 Pa (25 ° C); Henry's constant: 3.028 × 10-7 Pa · m3 / mol. Solubility (20 ℃): dej 3.88 mg / L (pH 5.84), 3.78 mg / L (pH 4.01), 3.44 mg / L (pH 7.00), 3.84 mg / L (pH 9.00); Cov kuab tshuaj organic (kev ntshiab 99.2) %) (g/L, 20℃): acetone>250, acetonitrile 167.6±0.2, dichloromethane 146.1±0.3, ethyl acetate 123.3±0.2, methanol 53.4±0.0, toluene 20.0±0.0, n-octanol 4.69±0.1, n-heptane 0.106±0.001. Cov coefficient ntawm kev faib n-octanol-dej (20°C): dej deionized log Kow 3.08, log Kow 3.09 (pH 4), log Kow 3.13 (pH 7), log Kow 3.09 (pH 9), nruab nrab log Kow (3.10±0.02). Ruaj khov hauv cov kua dej ntawm pH 4, 5, 7, 9 nyob rau hauv qhov tsaus ntuj thiab sterile tej yam kev mob. Lub teeb pom kev zoo ruaj khov.

Kev lom ntawm Fluoxafen

Kev lom tshuaj lom hauv qhov ncauj rau cov nas (poj niam) ntawm cov tshuaj fluconazole thawj: LD50≥2,000 mg / kg, kev lom tshuaj lom rau cov tawv nqaij hauv cov nas (txiv neej thiab poj niam): LD50> 2,000 mg / kg, kev lom tshuaj lom rau cov pa hauv cov nas (txiv neej thiab poj niam): LC50> 5.1 mg / L; me ntsis khaus rau lub qhov muag luav thiab daim tawv nqaij ntawm luav; tsis muaj kev cuam tshuam rau daim tawv nqaij npua guinea. Tsis muaj carcinogenicity, tsis muaj teratogenicity, tsis muaj kev phiv rau kev yug me nyuam, tsis muaj genotoxicity, neurotoxicity thiab immunotoxicity.
Kev lom rau cov noog LD50> 2,000 mg / kg, kev lom rau Daphnia 6.78 mg / L (48 h), kev lom rau ntses (96 h) LC50 0.546 mg / L, kev lom rau cov tsiaj txhu hauv dej (48 h)) EC50 6.78 mg / L, kev lom rau algae (72 h) EC50 0.70 mg / L, kev lom rau cov muv (48 h) LD50> 100 μg / muv, kev lom rau qhov ncauj rau muv (48 h) LD50> 110.9 μg / muv, kev lom rau cov kab laug sab hauv av yog LC50> 1,000 mg / kg (14 hnub). Los ntawm cov ntaub ntawv saum toj no, nws tuaj yeem pom tias Fluoxafen yog lom rau cov tsiaj txhu hauv dej thiab muaj kev lom tsawg rau lwm cov tsiaj txhu uas muaj txiaj ntsig.

Lub mechanism ntawm kev ua haujlwm ntawm fluoxafen

Fluoxafenamide yog ib qho tshuaj succinate dehydrogenase inhibitor, uas ua rau succinate dehydrogenase hauv mitochondrial respiratory chain complex II los tiv thaiv nws cov haujlwm, yog li ntawd inhibiting germination ntawm fungal pathogen spores, kev loj hlob ntawm cov hlab ntsha germ thiab mycelium.

Cov khoom tswj hwm Fluconazole

Fluoxamid muaj txiaj ntsig zoo, dav-spectrum, ruaj khov, xaiv tau, muaj kev coj ua zoo heev, thiab tiv taus nag los nag. Nws tuaj yeem tswj tau cov nplej, taum pauv, pob kws, rapeseed, ntoo txiv hmab txiv ntoo, zaub, thiab beets qab zib los ntawm kev kho nplooj thiab noob. , txiv laum huab xeeb, paj rwb, nyom thiab cov qoob loo tshwj xeeb, thiab lwm yam, xws li nplej, taum pauv, ntoo txiv hmab txiv ntoo thiab zaub uas tshwm sim los ntawm Concha, Botrytis cinerea, Powdery mildew, Cercospora, Puccinia, Rhizoctonia, Sclerotium Cov kab mob uas tshwm sim los ntawm cov kab mob fungal, botrytis cinerea, xeb, powdery mildew ntawm legumes, paj rwb blight, paj noob hlis thiab rapeseed kab mob uas tshwm sim los ntawm Alternaria, thiab lwm yam. Sau npe rau kev siv rau ntau dua 70 qoob loo los ntawm xyoo 2015, BASF lub hom phiaj yog sau npe rau kev siv rau ntau dua 100 qoob loo.

Fluoxafen muaj kev hloov pauv tau zoo, thiab muaj ntau hom khoom sib xyaw. Adexar (fluconazole + epoxiconazole) siv rau hauv cov nplej, barley, triticale, rye thiab oats los tswj cov hmoov av, nplooj blight, glume blight, stripe xeb thiab nplooj xeb. Priaxor (flufenapyr + pyraclostrobin) tau sau npe hauv Tebchaws Meskas rau taum pauv, txiv lws suav, qos yaj ywm thiab lwm yam qoob loo hauv daim teb, thiab muaj cov teebmeem tshwj xeeb rau kev tswj cov xim av taum pauv (Septoria glycines); Orkestra SC (flufenapyr + Pyraclostrobin) tau sau npe hauv Brazil rau taum pauv, txiv qaub, qos yaj ywm, dos, carrots, txiv apples, txiv nkhaus taw, dib, kua txob ntsuab, txiv lws suav, canola, txiv laum huab xeeb, taum pauv, paj noob hlis, sorghum, pob kws, nplej thiab paj (Chrysanthemum thiab paj yeeb), thiab lwm yam, tuaj yeem tswj cov xeb taum pauv Esxias, txhim kho cov photosynthesis ntawm cov qoob loo, thiab siv rau kev tswj hwm kab mob tiv thaiv kab mob. Priaxor D (flufenapyr + pyraclostrobin + tetraflufenazole) tau sau npe rau hauv Tebchaws Meskas rau kev tiv thaiv thiab tswj cov kab mob grey soybean uas tiv taus methoxyacrylate fungicides. Tus neeg sawv cev kho noob Obvius (flufenapyr + pyraclostrobin + metalaxyl) tau sau npe rau hauv Tebchaws Meskas thiab tuaj yeem tswj ntau yam kab mob ntawm cov noob qoob loo uas tsis khov kho.

Cov tshuaj tua kab mob succinate dehydrogenase inhibitor fungicides tau loj hlob sai heev nyob rau xyoo tas los no, thiab fluoxamid yog cov khoom lag luam tseem ceeb ntawm cov tshuaj tua kab mob no, ua tsaug rau nws qhov ua tau zoo, dav spectrum, kev ua haujlwm systemic, haum rau ntau yam qoob loo thiab lwm yam ntxwv. Tshwj xeeb, kev txhim kho tas mus li ntawm nws cov khoom sib xyaw tau nthuav dav cov kev tswj hwm thiab qhov ntau thiab tsawg ntawm cov qoob loo siv, thiab tau dhau los ua lub hlaws ci ntsa iab hauv kev lag luam fungicide.