Cov yam ntxwv ntawm kev ua ntawm fluconazole

Fluoxapyr yog carboxamidefungicidetsim los ntawm BASF.Nws muaj kev tiv thaiv zoo thiab kho cov haujlwm.Nws yog siv los tiv thaiv thiab tswj broad-spectrum fungal kab mob, yam tsawg kawg 26 hom kab mob fungal.Nws tuaj yeem siv rau ze li ntawm 100 cov qoob loo, xws li cov qoob loo, legumes, roj qoob loo, txiv laum huab xeeb, pome thiab pob zeb txiv hmab txiv ntoo ntoo, hauv paus thiab tuber zaub, txiv hmab txiv ntoo zaub thiab paj rwb, nplooj los yog noob kho.Fluoxafenamide yog ib qho succinate dehydrogenase inhibitor thiab cov tshuaj tua kab mob zoo heev tsim nyob rau xyoo tas los no.
Physicochemical zog ntawm fluconazole

Fluconazole Lub Npe: 3-(difluoromethyl)-1-methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide, 3-(difluoro Methyl)-1- methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide;CAS Nr .: 907204-31-3, Molecular formula: C18H12F5N3O.Molecular Luj: 381.31 g / molFluoxapyr (purity 99.3%) yog dawb rau beige khoom, tsis muaj ntxhiab, melting point 156.8 ℃, txheeb ze ntom ntom (20 ℃) ​​1.42 g / mL, decomposes ntawm 230 ℃, vapor siab (kwv yees): 2.7 × 10- 9 Pa ( 20 ° C), 8.1 × 10-9 Pa (25 ° C);Henry tus tsis tu ncua: 3.028 × 10-7 Pa·m3/mol.Solubility (20 ℃): dej 3.88 mg/L (pH 5.84), 3.78 mg/L (pH 4.01), 3.44 mg/L (pH 7.00), 3.84 mg/L (pH 9.00);organic hnyav (kev purity 99.2) %) (g / L, 20 ℃): acetone> 250, acetonitrile 167.6 ± 0.2, dichloromethane 146.1 ± 0.3, ethyl acetate 123.3 ± 0.2, methanol 503.40 ± 0. octanol 4.69 ± 0.1, n-heptane 0.106 ± 0.001.n-octanol-dej faib coefficient (20 ° C): deionized dej cav Kow 3.08, log Kow 3.09 (pH 4), log Kow 3.13 (pH 7), log Kow 3.09 (pH 9), nruab nrab cav Kow (3.10 ± 0.02 ) .Ruaj khov nyob rau hauv aqueous tov ntawm pH 4, 5, 7, 9 nyob rau hauv maub thiab sterile tej yam kev mob.Teeb pom kev ruaj khov.

Toxicity ntawm Fluoxafen

Mob qhov ncauj toxicity nyob rau hauv nas (poj niam) ntawm thawj cov tshuaj ntawm fluconazole: LD50 ≥2,000 mg / kg, mob dermal toxicity nyob rau hauv nas (txiv neej thiab poj niam): LD50> 2,000 mg / kg, mob inhalation toxicity nyob rau hauv nas (txiv neej thiab poj niam) LC50＞ 5.1 mg/L;me ntsis irritation rau luav qhov muag thiab tawv nqaij ntawm luav;tsis muaj rhiab heev rau guinea npua daim tawv nqaij.Tsis muaj carcinogenicity, tsis muaj teratogenicity, tsis muaj kev phiv ntawm kev yug me nyuam, tsis muaj genotoxicity, neurotoxicity thiab immunotoxicity.
Mob toxicity rau noog LD50＞2,000 mg/kg, mob toxicity rau Daphnia 6.78 mg/L (48 h), mob toxicity rau ntses (96 h) LC50 0.546 mg/L, mob toxicity rau dej invertebrates (48 h) 6 . mg/L, mob toxicity rau algae (72 h) EC50 0.70 mg/L, mob toxicity rau muv (48 h) LD50> 100 μg / muv, mob qhov ncauj toxicity rau muv (48 h) LD50> 110.9 μg/bee, Qhov mob toxicity rau cov tsiaj nyeg yog LC50> 1,000 mg / kg (14 hnub).Los ntawm cov ntaub ntawv saum toj no, nws tuaj yeem pom tias Fluoxafen yog tshuaj lom rau cov kab mob hauv dej thiab muaj cov tshuaj lom tsis zoo rau lwm cov kab mob uas muaj txiaj ntsig.

Mechanism ntawm kev ua ntawm fluoxafen

Fluoxafenamide yog ib qho succinate dehydrogenase inhibitor, uas ua rau succinate dehydrogenase nyob rau hauv mitochondrial respiratory chain complex II los inhibit nws cov haujlwm, yog li inhibiting germination ntawm fungal kab mob spores, kev loj hlob ntawm cov kab mob thiab mycelium.

Fluconazole tswj cov khoom

Fluoxamid muaj txiaj ntsig zoo, dav-spectrum, ruaj khov, xaiv, muaj kev ua haujlwm zoo heev, thiab tiv taus nag yaig.Nws tuaj yeem tswj tau cov nplej, taum pauv, pob kws, rapeseed, txiv hmab txiv ntoo ntoo, zaub, thiab qab zib beets los ntawm kev kho cov nplooj thiab noob., txiv laum huab xeeb, paj rwb, nyom thiab cov qoob loo tshwj xeeb, thiab lwm yam, xws li nplej, taum pauv, txiv hmab txiv ntoo thiab zaub los ntawm Concha, Botrytis cinerea, Powdery mildew, Cercospora, Puccinia, Rhizoctonia, Sclerotium Kab mob tshwm sim los ntawm kab noj hniav fungi, botrytis cinerea, xeb. , powdery mildew ntawm legumes, paj rwb blight, sunflower thiab rapeseed kab mob tshwm sim los ntawm Alternaria, thiab lwm yam. Sau npe siv rau ntau tshaj 70 cov qoob loo los ntawm 2015, BASF aims mus rau npe rau siv rau ntau tshaj 100 cov qoob loo.

Fluoxafen muaj zog yoog raws, thiab muaj ntau yam khoom sib xyaw.Adexar (fluconazole + Epoxiconazole) yog siv rau hauv cov nplej, barley, triticale, rye thiab oats los tswj cov kab mob mildew, nplooj blight, glume blight, kab txaij xeb thiab nplooj xeb.Priaxor (flufenapyr + pyraclostrobin) tau sau npe hauv Tebchaws Meskas rau cov taum pauv, txiv lws suav, qos yaj ywm thiab lwm yam qoob loo, thiab muaj cov txiaj ntsig tshwj xeeb ntawm kev tswj cov taum xim av (Septoria glycines);Orkestra SC (flufenapyr + Pyraclostrobin) tau sau npe hauv Brazil rau cov taum pauv, citrus, qos yaj ywm, dos, carrots, txiv apples, mangoes, melons, dib, tswb peppers, txiv lws suav, canola, txiv laum huab xeeb, taum raum, sunflowers, sorghum, pob kws, nplej thiab paj (Chrysanthemum thiab rose), thiab lwm yam., tuaj yeem tswj tau Asian soybean xeb, txhim khu cov photosynthesis ntawm cov qoob loo, thiab siv rau kev tswj kab mob.Priaxor D (flufenapyr + pyraclostrobin + tetraflufenazole) tau sau npe hauv Tebchaws Meskas rau kev tiv thaiv thiab tswj cov taum grey chaw uas tiv taus methoxyacrylate fungicides.Tus neeg sawv cev kho cov noob Obvius (flufenapyr + pyraclostrobin + metalaxyl) tau sau npe hauv Tebchaws Meskas thiab tuaj yeem tswj tau ntau yam kab mob ntawm cov noob qoob loo ntawm ntau cov qoob loo.

Cov succinate dehydrogenase inhibitor fungicides tau loj hlob sai nyob rau hauv xyoo tas los no, thiab fluoxamid yog cov khoom lag luam ntawm hom fungicides, ua tsaug rau nws cov kev ua haujlwm siab, dav spectrum, kev ua haujlwm zoo, tsim nyog rau ntau yam qoob loo thiab lwm yam ntxwv tshwj xeeb, kev nruam. txoj kev loj hlob ntawm nws cov khoom sib xyaw tau nthuav dav kev tswj hwm spectrum thiab thaj tsam ntawm kev siv cov qoob loo, thiab tau dhau los ua cov hlaws ci ntsa iab hauv kev ua lag luam fungicide.