Florfenicol side effect

       Florfenicolyog ib qho hluavtaws monofluoro derivative ntawm thiamphenicol, cov mis mos molecular yog C12H14Cl2FNO4S, dawb los yog dawb crystalline hmoov, tsis muaj ntxhiab, me ntsis soluble hauv dej thiab chloroform, me ntsis soluble hauv glacial acetic acid, soluble hauv Methanol, ethanol. Nws yog ib qho tshiab broad-spectrum tshuaj tua kab mob ntawm chloramphenicol rau veterinary siv, uas tau ntse tsim nyob rau hauv lub lig 1980s.

Nws yog thawj zaug ua lag luam hauv Nyij Pooj xyoo 1990. Hauv xyoo 1993, Norway tau pom zoo siv cov tshuaj los kho furuncle ntawm salmon. Xyoo 1995, Fab Kis, United Kingdom, Austria, Mexico thiab Spain tau pom zoo siv cov tshuaj rau kev kho mob ntawm cov kab mob ua pa ntawm bovine. Nws kuj tau pom zoo siv los ua cov khoom noj ntxiv rau npua hauv Nyiv thiab Mexico los tiv thaiv thiab kho cov kab mob kab mob hauv npua, thiab Tuam Tshoj tam sim no tau pom zoo cov tshuaj.

Nws yog cov tshuaj tua kab mob, uas ua rau muaj qhov dav-spectrum bacteriostatic nyhuv los ntawm inhibiting cov haujlwm ntawm peptidyltransferase, thiab muaj cov kab mob dav dav, suav nrog ntau yam.Gram-zoothiab cov kab mob tsis zoo thiab mycoplasma. Cov kab mob rhiab heev muaj xws li bovine thiab porcine Haemophilus,Shigella dysentery, Salmonella, Escherichia coli, Pneumococcus, Influenza bacillus, Streptococcus, Staphylococcus aureus, Chlamydia, Leptospira, Rickettsia, thiab lwm yam. Cov khoom no muaj peev xwm diffuse mus rau hauv cov kab mob hlwb los ntawm lipid solubility, feem ntau ua rau cov kab mob 50s transboppri subunitase, inhibits cov kab mob 50s, boostasis. cuam ​​tshuam txoj kev loj hlob ntawm peptidase, inhibits kev tsim ntawm peptide chains, yog li tiv thaiv cov protein synthesis, ua tiav Antibacterial lub hom phiaj. Cov khoom no yog absorbed sai sai los ntawm qhov ncauj tswj hwm, dav dav, muaj ib nrab-lub neej ntev, siab ntshav tshuaj concentration, thiab ntev cov ntshav tshuaj lub sij hawm.
Nyob rau hauv xyoo tas los no, ntau qhov me me thiab nruab nrab cov npua teb tau siv florfenicol rau kev kho mob txawm tias qhov xwm txheej ntawm tus npua, thiab siv florfenicol ua cov tshuaj khawv koob. Qhov tseeb, qhov no yog qhov txaus ntshai heev. Nws muaj cov txiaj ntsig zoo ntawm cov kab mob swine uas tshwm sim los ntawm Gram-zoo thiab tsis zoo cov kab mob thiab mycoplasma, tshwj xeeb tshaj yog tom qab kev sib xyaw ntawm florfenicol thiab doxycycline, cov nyhuv yog txhim kho, thiab nws muaj txiaj ntsig zoo hauv kev kho mob porcine thoracic swine atrophic rhinitis saw. Cocci, thiab lwm yam. muaj cov nyhuv curative zoo.
Txawm li cas los xij, qhov laj thawj yog vim li cas thiaj li txaus ntshai siv florfenicol tsis tu ncua yog vim muaj ntau yam kev mob tshwm sim ntawm florfenicol, thiab kev siv florfenicol mus ntev ua rau muaj kev phom sij ntau dua li qhov zoo. Piv txwv li, cov phooj ywg npua yuav tsum tsis txhob quav ntsej cov ntsiab lus no.

1. Yog tias muaj kab mob viral xws li pseudorabies swine fever nrog lub pob ntseg xiav nyob rau hauv npua teb, kev siv florfenicol rau kev kho mob feem ntau yuav dhau los ua ib qho kev sib koom ua ke ntawm cov kab mob viral, yog li yog cov kab mob saum toj no kis tau thiab muaj tom qab thaum kis tus kab mob. Lwm cov kab mob npua, tsis txhob siv florfenicol rau kev kho mob, nws yuav ua rau tus kab mob hnyav dua.
2. Florfenicol yuav cuam tshuam rau peb lub hematopoietic system thiab inhibit zus tau tej cov qe ntshav liab nyob rau hauv cov pob txha, tshwj xeeb tshaj yog yog hais tias peb cov npua suckling muaj ib tug txias los yog o pob qij txha. Pig plaub hau xim tsis zoo-zoo, kib plaub hau, tab sis kuj qhia cov tsos mob ntawm anemia, nws kuj yuav ua rau tus npua tsis noj ntev, tsim ib tug tawv nqaij npua.
3. Florfenicol yog embryotoxic. Yog tias florfenicol feem ntau siv thaum cev xeeb tub hauv cov qoob loo, qhov tshwm sim piglets yuav ua tsis tiav.
4. Kev siv florfenicol mus ntev yuav ua rau mob plab hnyuv thiab raws plab hauv npua.
5. Nws yog ib qho yooj yim ua rau cov kab mob thib ob, xws li exudative dermatitis tshwm sim los ntawm tus kab mob staphylococcus hauv npua lossis kab mob thib ob ntawm qee cov kab mob fungal dermatitis.
Txhawm rau ua kom tiav, florfenicol yuav tsum tsis txhob siv los ua ib qho tshuaj. Thaum peb siv lwm cov tshuaj tua kab mob uas muaj cov nyhuv tsis zoo thiab muaj kev sib xyaw ua ke (kev tshem tawm tus kab mob), peb tuaj yeem siv florfenicol thiab doxycycline ntawm sab. Acupuncture yog siv los kho cov kab mob intractable, thiab nws tsis pom zoo rau lwm yam xwm txheej.