Tshuaj tua kabkev tiv thaiv ntawm arthropods uas kis kab mob ntawm kev ua liaj ua teb, kws kho tsiaj thiab kev noj qab haus huv tseem ceeb ua rau muaj kev hem thawj rau ntiaj teb vector tswj cov kev pab cuam. Cov kev tshawb fawb yav dhau los tau pom tias cov ntshav nqus cov arthropod vectors muaj kev tuag ntau thaum noj cov ntshav uas muaj inhibitors ntawm 4-hydroxyphenylpyruvate dioxygenase (HPPD), qhov thib ob enzyme hauv tyrosine metabolism. Txoj kev tshawb no tau tshuaj xyuas qhov ua tau zoo ntawm β-triketone HPPD inhibitors tiv thaiv kab mob thiab pyrethroid-resistant kab mob ntawm peb tus kab mob loj, suav nrog yoov tshaj cum kis kab mob xws li malaria, kab mob sib kis xws li dengue thiab Zika, thiab cov kab mob tshwm sim xws li Oropuche thiab Usutu kab mob.
Qhov sib txawv ntawm cov tshuaj pleev ib ce, tarsal thiab vial daim ntawv thov txoj kev, daim ntawv thov txoj kev, kev xa tshuaj tua kab thiab lub sijhawm ua haujlwm.
Txawm li cas los xij, txawm hais tias qhov sib txawv ntawm kev tuag ntawm New Orleans thiab Muheza ntawm qhov koob tshuaj ntau tshaj, tag nrho lwm cov concentrations tau zoo dua hauv New Orleans (sensitive) dua li hauv Muheza (tiv taus) tshaj 24 teev.
Peb cov txiaj ntsig tau pom tias nitisinone tua yoov tshaj cum ntshav los ntawm kev sib cuag transtarsal, thaum mesotrione, sulfotrione, thiab tepoxiton tsis ua. Txoj kev tua no tsis muaj kev ntxub ntxaug ntawm yoov tshaj cum rhiab heev lossis tiv taus ntau yam tshuaj tua kab, suav nrog pyrethroids, organochlorines, thiab tej zaum carbamates. Tsis tas li ntawd, kev ua tau zoo ntawm nitisinone hauv kev tua yoov tshaj cum los ntawm kev nqus ntawm epidermal tsis txwv rau Anopheles hom, raws li pom los ntawm nws cov kev ua tau zoo tiv thaiv Strongyloides quinquefasciatus thiab Aedes aegypti. Peb cov ntaub ntawv txhawb nqa qhov xav tau rau kev tshawb fawb ntxiv los ua kom zoo dua nitisinone nqus, tejzaum nws los ntawm kev txhim kho tshuaj lom neeg ntawm epidermal absorption lossis ntxiv cov adjuvants. Los ntawm nws cov txheej txheem tshiab ntawm kev ua, nitisinone exploits cov ntshav nqus tus cwj pwm ntawm poj niam yoov tshaj cum. Qhov no ua rau nws yog ib tus neeg sib tw ua tau zoo rau cov tshuaj tua kab hauv tsev tshiab thiab cov tshuaj tua kab mob ntev ntev, tshwj xeeb tshaj yog nyob rau thaj chaw uas cov txheej txheem tswj yoov tshaj cum tsis muaj txiaj ntsig vim qhov tshwm sim sai ntawm pyrethroid tsis kam.
Post lub sij hawm: Aug-06-2025