Tshuaj kho tsiaj zoo Colistin Sulfate CAS 1264-72-8

Kev piav qhia txog khoom

Nws feem ntau muaj cov tshuaj tua kab mob zoo rau cov kab mob gram-negative, thiab cov kab mob rhiab heev suav nrog Pseudomonas aeruginosa, Escherichia coli, Enterobacteria, Klebsiella, Salmonella, Shigella, Pasteurella thiab Vibrio. Proteus, Brucella, Serratia thiab txhua yam kab mob Gram-positive tiv taus cov khoom no.Colistin Sulfaterau cov tshuaj tua kab mob qeeb, lub luag haujlwm tseem ceeb hauv cov kab mob cell membranes, thaum sib cuag nrog cov kab mob rhiab heev, nws cov qauv tshuaj ntawm cov amino dawb (Yang) thiab phosphate ester ntawm phosphoric acid hauv paus ntawm cov kab mob cell membrane (nrog electronegative), ua rau cov permeability ntawm membrane, ua rau cell ntawm cov tshuaj tseem ceeb xws li amino acids, Piao zaj nkauj, pyrimidine, K + ntawm nws.

Adaim ntawv thov

Nws feem ntau yog siv los kho cov kab mob hauv plab hnyuv uas tshwm sim los ntawm Grame-negative bacilli (Escherichia coli, thiab lwm yam). Nws kuj tseem siv tau zoo rau Pseudomonas aeruginosa (sepsis, urinary tract infection, burns lossis traumatic wound infection).

Cov yam ntxwv

(1) Nws muaj zog heev tiv taus cov kab mob Gram negative. Tshwj xeeb, nws muaj kev cuam tshuam tshwj xeeb rau Escherichia coli, Salmonella, thiab Pseudomonas aeruginosa.

(2) Nws muaj cov nyhuv tua kab mob. Los ntawm kev cuam tshuam qhov kev xaiv permeability ntawm cov cell membranes, cov kab mob tuag.

(3) Yuav luag tsis muaj teeb meem dab tsi nrog kev tiv thaiv tshuaj. Tsis pom muaj kev tiv thaiv rau R-factor.

(4) Nws ua haujlwm synergistically nrog cov tshuaj tiv thaiv kab mob Gram zoo. Thaum ua ke nrog zinc bacitracin, flavomycin, sulfonamides, semi synthetic penicillin, gentamicin, thiab lwm yam, cov nyhuv zoo dua.

(5) Tsis muaj cov khoom seem. Thaum noj los ntawm qhov ncauj, nws yuav luag tsis nqus los ntawm txoj hnyuv, tab sis thaum lub sijhawm txhaj tshuaj rau hauv cov leeg, kev sau ntshav thiab kev nqus tau zoo, yog li tsis tas yuav txhawj txog cov khoom seem hauv cov khoom tsiaj.

(6) Txhawb kev loj hlob ntawm cov tsiaj txhu thiab cov nqaij qaib, thiab tiv thaiv thiab tswj cov kab mob sib kis hauv cov tsiaj txhu thiab cov nqaij qaib.